The short answer: panels for speed, tile for the long haul
Start with the answer, because you came here for one. Acrylic shower wall panels are the fast, lower-cost, low-maintenance choice. Tile costs more and takes longer, and it pays you back in looks, resale, and a shower that's still there in twenty years. Panels win on speed and budget. Tile wins on the long haul.
That's the whole decision in two sentences. Everything below is just me showing my work, because 'it depends' is a useless answer and I promised you a real one.
What acrylic shower wall panels actually are
Let's define the thing. Acrylic shower wall panels are large molded plastic sheets that go over your shower walls, usually three or five big pieces that cover the whole surround. They glue and click into place, the seams get sealed, and you're done. Acrylic shower walls go from bare wall to finished in about a day, which is their entire superpower.
The honest case for them is real. There's almost no grout, so there's almost nothing to scrub (grout is the cement filler between tiles, and it's where mould throws its parties). The surface wipes clean. The labour is hours instead of days, so the cost is lower. For a lot of bathrooms that's genuinely the right call, and I'll say so to your face.
Where the water actually goes, and where showers fail
Here's the part that decides whether a shower lasts or rots, and almost nobody asks about it. Both options have to keep water out of your walls. They just do it in completely different places.
With waterproof paneling for shower walls, the panel itself is the waterproof layer. The plastic doesn't absorb water, so as long as the seams and edges are sealed properly, the wall behind stays dry. The weak point is the joints. A panel shower fails at a bad seam, not in the middle.
Tile is the opposite, and this is where people get burned. Tile and grout are not waterproof. Water passes through grout lines. The waterproofing on a tiled shower is a hidden membrane behind the tile (a waterproof sheet or coating, like Schluter's Kerdi), and the tile is just the pretty, tough armour bonded over it. Which brings me to the one strong opinion I'll plant here: cement board is the most expensive misunderstanding in bathroom remodelling. It is water-durable, not waterproof, and a tiled shower built on bare cement board with no membrane is soaking its framing every single day. ANSI A118.10 exists precisely because the board is not the waterproofing. Skip the membrane and the repair is a demolition, not a regrout.
So a panel shower done right and a tiled shower done right are both bone dry. A panel shower done cheap fails at the seams. A tiled shower done cheap fails behind the tile, where you can't see it until the ceiling below goes brown. Neither product is the villain. The install is.

Solid surface and the panels sitting in between
Panels aren't just thin cheap plastic anymore, and there's a middle tier worth knowing. Solid surface shower walls are made from the same dense material as a lot of countertops: thick, seamless-looking, and a real step up from basic acrylic in feel and in price. Cultured marble is a similar idea with a marble-look finish, and product lines like flexstone shower walls play in the same space.
These sit between acrylic and tile. Fewer seams than a basic panel kit, a more solid feel, less upkeep than tile, but still nowhere near the custom looks tile gives you. If you like the low-scrub life but thin plastic puts you off, this is the tier to look at. It's the sensible-shoes option, and sensible shoes are underrated.
What tile does that a panel never will
Now my side of the fence, and I'll keep it honest. Shower wall tile does things a molded panel physically cannot. A niche (a recessed shelf built into the wall for your shampoo) gets tiled right in. An accent stripe, a feature wall, a real stone look, a curbless walk-in with no step to trip on, a room that isn't a tidy rectangle: tile handles all of it. Panels come in fixed sizes and shapes. Tile gets cut to your actual room.
Tile also ages differently. A good tiled shower lasts twenty years and well beyond, and if a single tile ever cracks, you swap that one tile instead of the whole wall. It reads as a real bathroom to a buyer, where a plastic surround reads as a stopgap, so it adds resale value in a way panels don't. And texture is the giveaway: tile can be three-dimensional, ribbed, stone, handmade. A panel is a photo of that, printed flat.

So which one should you actually pick
Rule of thumb, and I give this one on the phone all the time. Go with panels if the shower is a rental, a fast flip, a basement bath nobody uses, or the budget and the calendar are both tight. Go with tile if it's your forever home, you care about resale, you want a niche or a curbless entry or a specific look, and you want it to outlive the next three shower-head trends.
Neither answer is wrong. The wrong move is paying for tile and getting a cheap install, or buying panels and expecting them to look custom. Match the product to the bathroom and the budget, and both of them make you happy.
When not to hire me, because sometimes panels win
I'd rather point you at the right product than sell you the wrong one, so here's when not to call me. If you're flipping a house next month, tile is slower and I won't pretend otherwise, get a good panel kit installed and move on. If it's a guest bathroom nobody sets foot in, the money is better spent elsewhere. If your timeline is 'showering by Saturday,' that's a panel job, not a tile job, and no amount of hustle from me changes the calendar.
When you want a shower tiled properly, waterproofed so it lasts, and built around your real room instead of a factory mold, that's my whole job. That's when to give us a call.
